Informatics Publishing Limited

Akash P. Dahake ¹, Arun B. Joshi ², Krunal M. Patel ³

Affiliations
1 Dept. of Pharma. Chemistry, B. Pharmacy College, Rampura, Kakanpur, Godhara, Gujarat, IN
2 N.G.S.M Institute of Pharm.Sciences, Paneer, Dearalaktte, Mangalore, IN
3 Pharmacy College, Rampura, Kakanpur, Godhara, Panchmahal, Gujarat, IN

Abstract

Increasing prevalence of multidrug resistant strains of microorganisms has initiated the exploration of alternate antimicrobial agent. Taking into account the medicinal importance of Dolichos Lablab (Fabaceae) in this respect, an attempt was made in the current study to investigate the antimicrobial potential of this plant. Antimicrobial activity of the ethanolic, petroleum ether, aqueous, chloroform, ethyl acetate and nhexane extracts of Dolichos Lablab beans were determined against various pathogenic bacteria and fungi. The extracts were tested against various bacteria like Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and fungi like Candida albicans by disk diffusion method. Minimum Inhibitory Concentration (MIC) values of each active extract were determined. It is concluded that n-Hexane and chloroform extract exhibited significant antimicrobial and antifungal activity.

Keywords

Dolichos Lablab, Antibacterial, Antifungal, Disk Diffusion Method.

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Tekeshwar Verma ¹, K. S. Chandrashekar ¹, Arun B. Joshi ¹

Affiliations
1 Department of Pharmaceutical Chemistry, NGSMIPS, Mangalore, IN

Abstract

Bauhinia purpurea, a useful medicinal plant was subjected to phytochemical investigation. A new ursane triterpenes α-amyrin caprylate (compound 1) was isolated along with other triterpenoids from petroleum ether fraction of ethanolic extract (95%) of leaf of Bauhinia purpurea. Their structures were elucidated with the help of physico-chemical methods and spectroscopic techniques. All of these triterpenes from this plant are being reported for the first time.

Keywords

Fabaceae, α-Amyrin Caprylate, Triterpenes.

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Akash P. Dahake ¹, D. Satyanarayana ¹, Arun B. Joshi ¹, K. S. Chandarshekhar ¹, Himanshu Joshi ¹

Affiliations
1 Dept. of Pharmacognosy, N.G.S.M Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore-574160, IN

Abstract

The investigation was carried out to study the antihyperglycemic effects of ethanolic extract of Anacardium occidentale leaves in normal, glucose loaded and alloxan induced diabetic rats. The ethanolic extract of A. occidentale at a dose of 100, 200, 400 mg/kg of body weight (p.o) and standard drug glibenclamide 500 μg/kg, in all three animal models. The serum glucose level was determined at 0, 4, 8 and 12 days after treatment. The extract exhibited significant hypoglycemic activity in all three animal models when compared with a standard antidiabetic agent Glibenclamide. The hypoglycemia produced by the extract may be due to increased uptake of glucose at tissue level and or increase in pancreatic β-cell function or due to inhibition of intestinal glucose absorption of glucose. The study indicated that the ethanolic extract of Anacardium occidentale is a potential antidiabetic agent and lends scientific support for it’s use in folk medicine.

Keywords

Anacardium occidentale, Diaebetes, Alloxan.

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Himanshu Joshi ¹, Arun B. Joshi ¹, Hemlata Sati ², M. P. Gururaja ¹, Prajwal R. Shetty ¹, E. V. S. Subrahmanyam ¹, D. Satyanaryana ¹

Affiliations
1 Dept. of Pharma. Chem., NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore –574160, IN
2 Department of Pharmacy, H.N.B Garhwal University, Srinagar Garhwal, Uttaranchal, IN

Abstract

The n-hexane extract of the ischolar_mains of Memecylon umbellatum yielded, octocosonoic acid, cerotic acid, ethyl palmitate, palmitic acid and butyric acid. The structural elucidation of the isolated compounds was based on spectral data (IR, ¹H NMR, ¹³C NMR, and mass spectroscopy).

Keywords

Memecylon umbellatum, N-Hexane Extract, Roots, Fatty Acids.

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